25(R,S)-Ruscogenin is a PI3K/Akt/mTOR signaling pathway inhibitor and TLR4 signaling inhibitor. It has been shown to suppress hepatocellular carcinoma (HCC) metastasis by reducing the expression of MMP-2, MMP-9, uPA, VEGF, and HIF-1α via regulating the PI3K/Akt/mTOR signaling pathway. Additionally, Ruscogenin alleviates LPS-induced pulmonary endothelial cell apoptosis by suppressing TLR4 signaling.
- Molecular weight is 430.62.
- Formula is C27H42O4.
- Appears as a white to off-white solid.
- Classified as a steroid.
- Initial sources include plants (Liliaceae Liriope platyphylla Wang et Tang) and microorganisms (Bacillus megaterium CGMCC 1.1741).